Preventive effect of Cynodon dactylon against ethylene glycol-induced nephrolithiasis in male rats

Authors

  • Abolfazl Khajavi Rad Department of Physiology, School of Medicine, Mashhad University of Medical Sciences, Mashhad, I. R. Iran
  • Mohammad- Hadi Sadeghian Department of Oncology, Mashhad University of Medical Sciences, Mashhad, I. R. Iran
  • Mousa-Al-Reza Hajzadeh Pharmacological Research Centre of Medicinal Plants, Mashhad University of Medical Sciences, Mashhad, I. R. Iran
  • Nooshin Hashemi Department of Biology, School of Science, Islamic Azad University, Mashhad Branch, I. R. Iran
  • Zakieh Keshavarzi Department of Physiology, Physiology Research Center, Kerman University of Medical Sciences, Kerman, I. R. Iran
  • Ziba Rajaei Department of Physiology, School of Medicine, Mashhad University of Medical Sciences, Mashhad, I. R. Iran
Abstract:

Objective: This study was carried out to investigate the preventive effects of hydroalcoholic extract of Cynodon dactylon(C.dactylon) roots on calcium oxalate calculi in rat. Materials and Methods: 24 Wistar rats were randomly divided into 4 groups: group A received tap drinking water while, Groups B, C, and D received 1% ethylene glycol daily for 28 days. Rats in groups C and D received ethanolic extract of C.dactylon at doses equivalent to 3.2 mg/kg and 12.6 mg/kg of root powder, respectively in drinking water from day 0 to day 28. Urine and blood were collected on days 0 and 28 and analyzed for biochemical elements. After 28 days, the kidneys were removed and prepared for histological evaluation of calcium oxalate deposits (CaOx). Results: The number of CaOx deposits in 10 microscopic fields of  kidney slices in group B was 24.5 ± 4.40 which was significantly higher than group A (p

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Journal title

volume 1  issue 1

pages  14- 23

publication date 2011-06-01

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